Daily we hear the word vaccine. If we could develop one against the corona virus we’d be home free to returning to normal. There are as many opinions about this as there are people on this planet. Will it be safe considering how fast things are moving to develop it? Will it provide protection for more than a few months? No one right now has any answers but what we do know is that vaccines and the concept of vaccination has been around for a long time.
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The word vaccine and vaccination are derived from Variolae vaccinae (smallpox of the cow), the term devised by Edward Jenner to denote cowpox. He used it in 1798 in the long title of his Inquiry into the Variolae vaccinae Known as the Cow Pox, in which he described the protective effect of cowpox against smallpox. In 1881, to honor Jenner, Louis Pasteur proposed that the terms should be extended to cover the new protective inoculations then being developed.
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A brief history (thanks to Wikipedia)
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(It is ironic that given our current corona virus comes from China, they led the way centuries ago with an early method to inoculate people from the smallpox virus.)
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Prior to the introduction of vaccination with material from cases of cowpox (heterotypic immunization), smallpox could be prevented by deliberate inoculation of smallpox virus, later referred to as variolation to distinguish it from smallpox vaccination. The earliest hints of the practice of inoculation for smallpox come during the 10th century in China. The Chinese also practiced the oldest documented use of variolation, dating back to the fifteenth century. They implemented a method of “nasal insufflation” administered by blowing powdered smallpox material, usually scabs, up the nostrils. Various insufflation techniques have been recorded throughout the sixteenth and seventeenth centuries within China. Two reports on the Chinese practice of inoculation were received by the Royal Society in London in 1700; one by Dr. Martin Lister who received a report by an employee of the East India Company stationed in China and another by Clopton Havers.
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Sometime during the late 1760s while serving his apprenticeship as a surgeon/apothecary Edward Jenner learned of the story, common in rural areas, that dairy workers would never have the often-fatal or disfiguring disease smallpox, because they had already contracted cowpox, which has a very mild effect in humans. In 1796, Jenner took pus from the hand of a milkmaid with cowpox, scratched it into the arm of an 8-year-old boy, James Phipps, and six weeks later inoculated (variolated) the boy with smallpox, afterwards observing that he did not catch smallpox. Jenner extended his studies and in 1798 reported that his vaccine was safe in children and adults and could be transferred from arm-to-arm reducing reliance on uncertain supplies from infected cows. Since vaccination with cowpox was much safer than smallpox inoculation, the latter, though still widely practiced in England, was banned in 1840.
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The second generation of vaccines was introduced in the 1880s by Louis Pasteur who developed vaccines for chicken cholera and anthrax, and from the late nineteenth century vaccines were considered a matter of national prestige, and compulsory vaccination laws were passed.
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The twentieth century saw the introduction of several successful vaccines, including those against diphtheria, measles, mumps, and rubella. Major achievements included the development of the polio vaccine in the 1950s and the eradication of smallpox during the 1960s and 1970s. However, vaccines remain elusive for many important diseases, including herpes simplex, malaria, gonorrhea, and HIV.
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Today we are searching at “warp speed” for a vaccine for the corona virus. Will one be developed or will we have to live with this virus like we do with HIV? Only time will tell.